# R1 — MEME episodic-selection sites per host × gene

`p05` = sites p≤0.05 · `q05` = FDR-significant sites q≤0.05 · `q05/100var` = FDR-sig per 100 variable codons (length-normalized).

| gene | host | class | codons | variable | p≤0.05 | q≤0.05 | q05/100var |
|------|------|-------|-------:|---------:|-------:|-------:|-----------:|
| HA | N.Am avian | avian | 580 | 512 | 208 | 80 | 15.62 |
| HA | Eurasian avian | avian | 580 | 526 | 213 | 85 | 16.16 |
| HA | swine | mammal | 580 | 555 | 219 | 112 | 20.18 |
| HA | human | mammal | 580 | 510 | 140 | 59 | 11.57 |
| HA | equine | mammal | 580 | 303 | 37 | 2 | 0.66 |
| HA | canine | mammal | 580 | 185 | 13 | 0 | 0.00 |
| NA | N.Am avian | avian | 477 | 373 | 57 | 5 | 1.34 |
| NA | Eurasian avian | avian | 477 | 405 | 34 | 1 | 0.25 |
| NA | swine | mammal | 477 | 355 | 58 | 2 | 0.56 |
| NA | human | mammal | 477 | 272 | 41 | 1 | 0.37 |
| NA | equine | mammal | 477 | 123 | 10 | 0 | 0.00 |
| NA | canine | mammal | 477 | 72 | 3 | 0 | 0.00 |
| PB1 | N.Am avian | avian | 772 | 203 | 37 | 0 | 0.00 |
| PB1 | Eurasian avian | avian | 772 | 258 | 57 | 0 | 0.00 |
| PB1 | swine | mammal | 772 | 420 | 100 | 0 | 0.00 |
| PB1 | human | mammal | 772 | 241 | 22 | 1 | 0.41 |
| PB1 | equine | mammal | 772 | 110 | 24 | 0 | 0.00 |
| PB1 | canine | mammal | 772 | 99 | 12 | 0 | 0.00 |

## M2 roll-up: avian vs mammal, q≤0.05 FDR-significant sites

| gene | avian hosts (q05 each) | mammal hosts (q05 each) |
|------|------------------------|-------------------------|
| HA | N.Am avian=80, Eurasian avian=85 | swine=112, human=59, equine=2, canine=0 |
| NA | N.Am avian=5, Eurasian avian=1 | swine=2, human=1, equine=0, canine=0 |
| PB1 | N.Am avian=0, Eurasian avian=0 | swine=0, human=1, equine=0, canine=0 |